The quantity and percentage of the most typical antagonistic reactions that occurred at any time in the course of the research in ≥ 4% of XENAZINE-handled patients, and with a higher frequency than in placebo-treated sufferers, are offered in Table 1. In a randomized, 12-week, placebo-controlled medical trial of HD sufferers, opposed reactions have been more common in the XENAZINE group than in the placebo group. Forty-9 of 54 (91%) sufferers who obtained XENAZINE experienced one or more antagonistic reactions at any time during the research. The most common adverse reactions have been (over 10%, and no less than 5% larger than placebo) had been sedation/somnolence, fatigue, insomnia, despair, akathisia, and nausea. The elimination half-lifetime of tetrabenazine in topics with hepatic impairment was approximately 17.5 hours. The publicity to α-HTBZ and β-HTBZ was roughly 30% to 39% larger in patients with liver impairment than in age-matched controls.
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Female RX Oil isn’t just a lubricant however a sexual goddess in relation to feminine sexual enhancement since it has a really highly effective arousal effects. The Really Cheeky Adult Fun Board Game For Friends 2 8 Players is bought as a juice or a gel — it isn’t an oil and it’ll not degrade a condom. Sex in ladies wants a specialised consideration since age and hormones play a significant position. You might be experiencing a great intercourse life then abruptly the sexual urge disappears or it declines with time. Most ladies have a problem reaching orgasm or they’re fully unsatisfied when making love to their partners. Both men and women who had misplaced their sexual curiosity need not worry since there may be hope for them. This product would offer you a thrilling intense expertise as if it’s your first time. Silicone oils could have toxic unwanted effects, and as with petroleum-primarily based merchandise, they could coat your skin, affecting its normal features and permeability. Silicone can have many names on product labels, together with dimethicone, extremely polymerized methyl polysilozane, methyl polysiloxane, mirasil DM 20, and viscasil 5M. XENAZINE ought to be titrated up slowly at weekly intervals by 12.5 mg day by day, to allow the identification of a tolerated dose that reduces chorea. If a dose of 37.5 to 50 mg/day is required, it should be given in a three times a day routine. If adverse reactions similar to akathisia, restlessness, parkinsonism, depression, insomnia, nervousness or sedation occur, titration ought to be stopped and the dose ought Black Leather Neck And Wrist Restraints For Bondage to be lowered. Drugs.com provides correct and impartial data on more than 24,000 prescription drugs, over-the-counter medicines and pure products. This material is provided for educational functions only and is not meant for medical recommendation, prognosis or remedy. In 48-week and 80-week, open-label studies, sedation/somnolence occurred in 17% and 57% of XENAZINE-treated patients, respectively. In some patients, sedation occurred at doses that have been lower than recommended Discreet Personal Trainer Sex Simulator Masturbator Cup For Men doses. Recurrence of NMS has been reported with resumption of drug remedy. If remedy with XENAZINE is required after restoration from NMS, sufferers ought to be monitored for signs of recurrence. The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original worth. One study showed a big enhancement of UV induced pores and skin tumours in hairless mice handled with Metronidazole intraperitoneally (15μg per g physique weight and per day for 28 weeks). Although the importance of those research to man is not clear, patients ought to be suggested to keep away from or minimise publicity of metronidazole handled sites to solar. Patients who’re PMs of XENAZINE may have substantially higher levels of the first drug metabolites (about 3-fold for α-HTBZ and 9-fold for β-HTBZ) than sufferers who’re EMs. The dosage ought to be adjusted based on a affected person’s CYP2D6 metabolizer standing. In patients who’re recognized as CYP2D6 PMs, the utmost beneficial complete every day dose is 50 mg and the utmost really helpful single dose is 25 mg . Before prescribing a day by day dose of XENAZINE that’s greater than 50 mg/day, patients should be genotyped to find out in the event that they express the drug metabolizing enzyme, CYP2D6. The results of food on the bioavailability of XENAZINE have been studied in topics administered a single dose with and without food. Food had no impact on mean plasma concentrations, Cmax, or the world underneath the concentration time course of α-HTBZ or β-HTBZ . After a single oral dose of radiolabeled tetrabenazine, radioactivity was still detected in eye and fur at 21 days post dosing . There aren’t any data on the presence of tetrabenazine or its metabolites in human milk, the results on the breastfed infant, or the consequences of the drug on milk production.
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In a 12-week, double-blind, placebo-controlled trial in sufferers with chorea associated with HD, sedation/somnolence occurred in 17/fifty four (31%) of XENAZINE-treated sufferers and in 1 (three%) of placebo-treated patient. Sedation was the rationale upward titration of XENAZINE was stopped and/or the dose of XENAZINE was decreased in 15/54 (28%) patients. In all but one case, decreasing the dose of XENAZINE resulted in decreased sedation. CYP2D6 testing is important to find out whether sufferers are poor metabolizers , extensive or intermediate metabolizers of XENAZINE. Huntington’s illness is a progressive dysfunction characterized by adjustments in temper, cognition, chorea, rigidity, and practical capacity over time. In a 12-week controlled trial, XENAZINE was additionally proven to cause slight worsening in mood, cognition, rigidity, and practical capability. Whether these results persist, resolve, or worsen with continued remedy is unknown. α-HTBZ is subsequently metabolized to a minor metabolite, 9-desmethyl-α-DHTBZ. β-HTBZ is subsequently metabolized to a different major circulating metabolite, 9-desmethyl-β-DHTBZ, for which Cmax is reached roughly 2 hours publish-dosing. Because rats dosed orally with tetrabenazine do not produce 9-desmethyl-β-DHTBZ, a serious human metabolite of tetrabenazine, the metabolite was directly administered to pregnant and lactating rats. The no-effect dose for developmental toxicity in rats (eight mg/kg/day) was associated with plasma exposures of 9-desmethyl-β-DHTBZ in pregnant rats decrease than that in humans on the MRHD. It could also be troublesome to differentiate between antagonistic reactions and progression of the underlying disease; decreasing the dose or stopping the drug might help the clinician distinguish between the Fleshlight Go Torque Clear Travel Size Vagina Male Masturbator two possibilities. In some patients, underlying chorea itself may enhance over time, reducing the need for XENAZINE. Doses above 50 mg/day ought to be given in a three times a day regimen. This dose is equal to the oral consumption of 12 tubes of 30g packaging Rozex Gel for an grownup weighing seventy two kg, and a pair of tubes of Gel for a kid weighing 12 kg. Because of the minimal absorption of metronidazole and consequently its insignificant plasma focus after topical administration, the antagonistic experiences reported with the oral form of the drug haven’t been reported with Rozex Gel. Adverse reactions reported with Rozex Gel have been only native and gentle. You are left feeling that you need to never have intercourse anymore since there isn’t a desire.
It may be troublesome to tell apart between adverse reactions and progression of the underlying disease; decreasing the dose or stopping the drug may help the clinician distinguish between the 2 prospects.
In some sufferers, underlying chorea itself may enhance over time, lowering the necessity for XENAZINE.
The maximum beneficial daily dose is 100 mg and the maximum beneficial single dose is 37.5 mg.
Doses above 50 mg/day must be given in a three times a day regimen.
Tetrabenazine had no results on embryofetal development when administered to pregnant rabbits through the interval of organogenesis at oral doses up Toy Joy Helix 7 Speed Waterproof Vibrating Love Egg to 60 mg/kg/day (or 12 occasions the MRHD on a mg/m2 foundation). Sedation is the most common dose-limiting adverse reaction of XENAZINE. The efficacy of XENAZINE as a remedy for the chorea of Huntington’s disease was established primarily in a randomized, double-blind, placebo-controlled multi-center trial carried out in ambulatory sufferers with a analysis of HD. The prognosis of HD was primarily based on household history, neurological exam, and genetic testing. Treatment duration was 12 weeks, together with a 7-week dose titration interval and a 5-week upkeep interval followed by a 1-week washout. After oral administration, tetrabenazine is extensively hepatically metabolized, and the metabolites are primarily renally eradicated. Following treatment interruption of larger than 5 days, XENAZINE remedy must be re-titrated when resumed. For quick-time period therapy interruption of lower than 5 days, remedy could be resumed on the previous maintenance dose without titration. Both the cream and the gel comprise the same energy of the energetic ingredient and are thought-about to work in the same means, so the choice between the two products is a personal choice. The daily dose of XENAZINE mustn’t exceed 50 mg per day and the maximum single dose of XENAZINE should not exceed 25 mg in affected person staking sturdy CYP2D6 inhibitors . Dose escalation was discontinued or dosage of examine drug was decreased due to one or more antagonistic reactions in 28 of 54 (fifty two%) patients randomized to XENAZINE. These adverse reactions consisted of sedation , akathisia , parkinsonism , melancholy , nervousness , fatigue and diarrhea . Some patients had more than one AR and are, due to this fact, counted greater than once.
No compound-related dermal or systemic effects were observed in a 13-week cutaneous route toxicity study, by which Rozex gel containing Metronidazole zero.seventy five% w/w was applied day by day to rabbits at doses ranging between 0.13 and 13 mg/kg. The toxicity research performed with the Metronidazole zero.seventy five% Topical Gel formulation reveal that the product is non-toxic in rats after acute oral administration 5g/kg and produced no ocular irritation in rabbit eyes. The formulation produced no observable results Vac U Lock Nude Double Penetrator Dildo Attachment in rabbits after dermal application of thirteen mg /kg for 90 days. In most sufferers at most time factors after Rozex Gel application, serum concentrations of metronidazole were under the detectable limits of the assay (25 ng/ml). Acute oral toxicity studies with a topical gel formulation containing 0.seventy five% w/w metronidazole in rats have shown no toxic motion with doses of as much as 5 g of finished product per kilogram body weight, the best dose used. Administration of tetrabenazine to rats throughout being pregnant and lactation resulted in a rise in stillbirths and postnatal offspring mortality. Administration of a major human metabolite of tetrabenazine to rats throughout being pregnant or during pregnancy and lactation produced antagonistic effects on the growing fetus and offspring . The antagonistic developmental effects of tetrabenazine and a significant human metabolite of tetrabenazine in rats occurred at clinically relevant doses . The safety and efficacy of this increased publicity to tetrabenazine and different circulating metabolites are unknown so that it is not attainable to regulate the dosage of tetrabenazine in hepatic impairment to ensure protected use. Therefore, XENAZINE is contraindicated in patients with hepatic impairment . There aren’t any sufficient data on the developmental danger associated with the use of XENAZINE in pregnant women.
Pjur Woman Nude Water Based Personal Intimate Sex Lube 100ml recommended daily dose is a hundred mg and the utmost really helpful single dose is 37.5 mg. If antagonistic reactions such as akathisia, parkinsonism, depression, insomnia, nervousness or sedation occur, titration should be stopped and the dose should be reduced. In patients with hepatic impairment, tetrabenazine plasma concentrations have been similar to or higher than concentrations of α-HTBZ, reflecting the markedly decreased metabolism of tetrabenazine to α-HTBZ. The imply tetrabenazine Cmax in topics with hepatic impairment was roughly 7- to a hundred ninety-fold larger than the detectable peak concentrations in healthy topics. Data sources embody IBM Watson Micromedex , Cerner Multum™ , Wolters Kluwer™ and others. Valentra cream awakens the sexual urge that you simply had been worried about which takes lower than two minutes. A variety of creams include chemical substances which irritate after utilizing, however Velantra cream doesnt because its prepared from pure products. Any thrust ensures an electrifying feeling with sexual arousal. There was an approximately 30% increase in Cmax and an approximately 3-fold improve in AUC for α-HTBZ in topics given paroxetine previous to tetrabenazine compared to tetrabenazine given alone. For β-HTBZ, the Cmax and AUC were increased 2.four- and 9-fold, respectively, in topics given paroxetine previous to tetrabenazine given alone. The elimination half-lifetime of α-HTBZ and β-HTBZ was approximately 14 hours when tetrabenazine was given with paroxetine. Following oral administration of tetrabenazine, the extent of absorption is no less than 75%. Peak plasma concentrations of α-HTBZ and β-HTBZ are reached inside 1 to 1½ hours publish-dosing.
At the Week thirteen comply with-up in Study 1 , the Total Chorea Scores of sufferers receiving XENAZINE returned to baseline. In vitro studies indicate that α-HTBZ and β-HTBZ are substrates for CYP2D6. α-HTBZ, β-HTBZ and 9-desmethyl-β-DHTBZ have half-lives of seven hours, 5 hours and 12 hours respectively. In a mass stability research in 6 healthy volunteers, roughly seventy five% of the dose was excreted in the urine, and fecal restoration accounted for approximately 7 to 16% of the dose. Urinary excretion of α-HTBZ or β-HTBZ accounted for less than 10% of the administered dose. Circulating metabolites, including sulfate and glucuronide conjugates of HTBZ metabolites as well as merchandise of oxidative metabolism, account for the majority of metabolites within the urine.
The purpose it’s so usually used in intercourse lubricants is that it emulates the pure lubrication of a girl’s vagina. As proven in Figure 1, Total Chorea Scores for patients within the drug group declined by an estimated 5.zero models during upkeep remedy , in comparison with an estimated 1.5 models in the placebo group.
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Because rigidity can develop as a part of the underlying illness course of in Huntington’s illness, it might be tough to tell apart between this drug-induced antagonistic reaction and development of the underlying disease course of. Drug-induced parkinsonism has the potential to trigger extra functional incapacity than untreated chorea for some sufferers with Huntington’s disease. If a affected person develops parkinsonism during remedy with XENAZINE, dose reduction should be thought of; in some sufferers, discontinuation of therapy may be essential. The beginning dose ought to be 12.5 mg/day given once in the morning. After 1 week, the dose should be increased to 25 mg/day given as 12.5 mg twice a day.
Sexy Black Lace Party Masquerade Queen Eye Mask Women =’display: block;margin-left:auto;margin-right:auto;’ 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” 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